one The subsequent adverse reactions happened in at least five% of Depakote-dealt with people and at an equivalent or increased incidence for placebo than for Depakote: flu syndrome and pharyngitis.
severe multiorgan reactions. Treatment with DEPAKOTE may perhaps bring about intense multiorgan reactions that can be life-threatening or may perhaps bring on Demise. Halt getting DEPAKOTE, and contact your Health care supplier or get healthcare help at once when you produce any of such signs or symptoms of a serious pores and skin response:
Evidence implies that folic acid supplementation prior to conception And through the main trimester of pregnancy decreases the risk for congenital neural tube defects in the general populace [see Use in Specific Populations (eight.1)].
There is not any entire body of proof out there from controlled trials to information a clinician while in the lengthier term management of the client who increases all through Depakote treatment method of an acute manic episode. Though it is usually agreed that pharmacological remedy further than an acute reaction in mania is appealing, each for servicing on the First reaction and for avoidance of latest manic episodes, there isn't any knowledge to support the key benefits of Depakote in these types of extended-expression treatment method.
All Girls of childbearing age (which include girls from the start of puberty) need to discuss for their healthcare provider about employing other doable treatments as an alternative to Depakote. If the choice is made to work with Depakote, you must use helpful start Manage (contraception).
Never end taking valproate or change your dose without conversing with your overall health care company initial.
Consider Depakote specifically as your healthcare company lets you know. Your Health care company will show you the amount Depakote to consider and when to acquire it.
For that reason, Health care suppliers who elect to employ Depakote for extended durations must continually reevaluate the lengthy-expression usefulness in the drug for the individual affected person.
are breastfeeding. Depakote can pass into breast milk and could damage your toddler. Speak with your Health care provider about The easiest method to feed your toddler if you're taking Depakote.
Depakote was statistically drastically exceptional to placebo on all a few measures of consequence. An exploratory Examination get more info for age and gender consequences on end result didn't recommend any differential responsiveness on The premise of age or gender.
There are already stories of acute or subacute encephalopathy from the absence of elevated ammonia concentrations, elevated valproate concentrations, or neuroimaging variations. The encephalopathy reversed partly or absolutely just after valproate discontinuation.
For those who pass up a dose of DEPAKOTE ER tablets or DEPAKOTE delayed-launch tablets, just take it the moment you keep in mind Unless of course it’s almost time for your up coming dose. Consider the next dose at your regular time. Do not take two doses concurrently.
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